Congenital vs Inherited
- Congenital
- Type II most common and least serious
- Factor V Leiden - Mutation in Factor V so it can't be degraded by Protein C
- Prothrombin G20210A (2-3x) - high levels of prothrombin due to pre-mRNA stability
- Type I less common and more serious
- Protein S and C deficiency (5-10x)
- Antithrombin III deficiency (BTW heparin increases activity of antithrombin 3000x)
- Acquired
- Antiphospholipid syndrome - abs vs cell membrane phospholipids (lupus anticoagulant, anticardiolipin antibodies, anti-B2glycoprotein 1 antibodies)
- HIT
- Nephrotic syndrome, pregnancy, estrogen
